Nr1h4 | nuclear receptor subfamily 1, group H, member 4
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Hematopoietic system Behavior/neurological
16 No significant impact
4 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:13Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased startle reflex | 5 supporting datasets | Nr1h4Nr1h4 | homozygote | Early adult | 9.21x10-6 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Nr1h4Nr1h4 | homozygote | Early adult | 5.25x10-12 | ||
| increased lactate dehydrogenase level | 1 supporting dataset | Nr1h4Nr1h4 | homozygote | Early adult | 2.12x10-6 | ||
| increased circulating triglyceride level | 2 supporting datasets | Nr1h4Nr1h4 | homozygote | Early adult | 3.07x10-13 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Nr1h4Nr1h4 | homozygote | Early adult | 6.53x10-22 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Nr1h4Nr1h4 | homozygote | Early adult | 6.76x10-7 | ||
| increased circulating cholesterol level | 2 supporting datasets | Nr1h4Nr1h4 | homozygote | Early adult | 1.87x10-22 | ||
| decreased locomotor activity | 1 supporting dataset | Nr1h4Nr1h4 | homozygote | Early adult | 2.02x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Nr1h4Nr1h4 | homozygote | Early adult | 1.15x10-22 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Nr1h4Nr1h4 | homozygote | Early adult | 8.14x10-10 |
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Human diseases caused by Nr1h4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Nr1h4.
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| Nr1h4tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Nr1h4tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Nr1h4tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Nr1h4tm41590(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |